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Pregnenolone 100 mg - 60 Capusles

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Improves memory and mood, reduces stress and allergic reactions.

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Pregnenolone is a precursor hormone made primarily in the adrenal glands, but also in the brain, liver, skin, and ovaries. It can convert to DHEA and progesterone and all the adrenal steroid hormones, including testosterone and estrogen.

Pregnenolone improves memory and mood, reduces stress and allergic reactions such as rheumatoid arthristis.

1. What is Pregnenolone ?
Pregnenolone is a natural hormone made from cholesterol in the body. It is synthesized inside the thousands of mitochondria which are tiny "power plants" found in each cell.

The saponin, diosgenin, found in wild Yam (Igname ) is the starting material for the synthesis of a number of hormonal products such as pregnenolone.

However, it is important to note that the human body does not have the ability to convert diosgenin into pregnenolone, and thus consuming wild yam cannot help in increasing pregnenolone production.

Pregnenolone levels, like DHEA levels, decline with age: we produce 60% less pregnenolone at age 75 than at age 35.

2. What is Pregnenolone used for ?
DHEA is often called the "mother hormone". The term would be better applied to pregnenolone, which is the precursor for the production of all the human steroid hormones, including DHEA, progesterone, estrogen, testosterone, cortisol and aldosterone. But pregnenolone is not itself steroid hormone.
The part of the pregnenolone which is not metabolized carries out other important specific functions.

3. What are the benefits of Prenenolone supplementation ?
Pregnenolone has been found to be an extremely powerful memory enhancer. The mechanism for this action is not fully known but probably involves a number of mechanisms. One possibility is that pregnenolone acts on acetylcholine, a brain chemical involved in memory.

Several studies showed that pregnenolone enhance several aspects of neurological functioning, including cognitive benefits such as enhancing learning and memory, and motor-nerve effects such as improved psychomotor performance.

Pregnenolone has been found to be 100 times more effective for memory enhancement than other steroids or steroid-precursors in laboratory mice. Dr. Eugene Roberts, PHD says about pregnenolone, "appears to be the most potent memory enhancer yet reported in animals." *1

One of the most important action of pregnenolone is that it to counter damage caused by the natural stress hormone, released by the adrenal glands, called "cortisol". Modest amounts of cortisol are helpful but high levels are toxic.

Pregnenolone actions include limiting allergic reactions and reducing inflammatory processes, such as arthritis.

As pregnenolone naturally converts into DHEA and progesterone it is often used in natural Hormone Replacement Therapy because results can be obtained with lower doses.

*1 Source: Flood JF, Morley JE, Roberts E. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc Natl Acad Sci 1992;89:1567–71.

4. What is the recommended dosage, and are there any side effects ?
A typical recommended dosage of pregnenolone is 50 mg to be taken daily in the morning or at midday.

Higher dosages can be taken by persons suffering from rheumatoid arthritis further to their healthcare professional's advice.

Pregnenolone absorption can raise pregnenolone levels during more than 24 hours if pregnenolone quality is good.

Dr. Eugene Roberts gave 20 Alzheimers patients 525 mg daily during three months with no toxicity. Dr. H. Freeman and colleagues gave patients with rheumatoid arthritis 500 mg pregnenolone daily during 30 weeks without noting any side effects. Two of the pioneer of researchers on pregnenolone, Drs. Pincus and Hoagland, found no toxic reactions with pregnenolone used by hundreds of men and women at dosages of 100 mg/day for four months.

Consumers willing to take pregnenolone for a long time period are recommended to realize a salivary test every year in order to adjust their pregnenolone intake to their need.

5. Can one take DHEA and Pregnenolone simultaneously ?
Dr. Regelson feels the right approach is to take pregnenolone with DHEA because hormones work best when they work in tandem*1

Indeed, part of the pregnenolone intake will be converted into DHEA but the amount of conversion is very small. Pregnenolone intake can only raise marginally DHEA levels in the body.

Pregnenolone and DHEA combination may be justified because pregnenolone acts in a metabolic way and a neuro-specific manner as progesterone /Cortisol.

*1 Source: Regelson, William, M.D. and Carol Colman. The Superhormone Promise. New York: Simon & Schuster, 1996.

6. Take good quality Pregnenolone
Consumers willing to buy good quality pregnenolone must look for laboratories observing "Good Manufacturing Practices" (GMP) guaranteeing that pregnenolone produced is pure at more than 99%. Our pregnenolone is pure at more than 99%.

packaging unit 60 capsules - 100 mg
composition Each capsule provides 100mg of pharmaceutical grade pregnenolone. This pregnenolone is manufactured under GMP (Good manufacturing Practices) conditions, which guarantee its quality and potency.
recommended intake Take one capsule in the morning on an empty stomach, or as recommended.
additional advice Do not take more than the recommended dosage. Keep out of reach of children. For adults only. Not intended for pregnant or lactating women.

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